Description

1-(3-Carboxypropylcarbamoyl)-5-Fluorouracil is a chemically modified derivative of the antimetabolite 5-fluorouracil (5-FU), designed to act as a prodrug for targeted therapeutic delivery. This compound is significant for its potential to enhance drug stability, reduce systemic toxicity, and improve tumor selectivity in oncology applications. It is primarily needed by pharmaceutical research and development teams, fine chemical manufacturers, and academic institutions engaged in the synthesis of novel anticancer agents and prodrug systems.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel chemotherapeutic prodrugs and targeted cancer therapies.
• Oncology Research: Used in preclinical studies to investigate modified 5-FU derivatives with improved pharmacokinetic profiles and reduced side effects.
• Prodrug Development: Serves as a model compound for designing molecules that release 5-fluorouracil in a controlled or enzyme-triggered manner at the tumor site.
• Bioconjugation Studies: Utilized in developing antibody-drug conjugates (ADCs) or polymer-drug conjugates due to its carboxylic acid functional group for linkage.
• Chemical Biology: Acts as a tool compound to study nucleotide metabolism and the mechanisms of action of fluoropyrimidines.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized pharmaceutical projects.

Basic Information

Product Name	1-(3-Carboxypropylcarbamoyl)-5-Fluorouracil
CAS No.	69519-16-0
Molecular Formula	C9H10FN3O5
Molecular Weight	259.19 g/mol
Synonyms	5-Fluorouracil-1-(3-carboxypropylcarboxamide); 1-(3-Carboxypropylcarbamoyl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-FU-CPC; N1-(3-Carboxypropyl)-5-fluorouracil-1-carboxamide; 5-Fluorouracil N1-carboxypropylamide; 1-Carbamoyl-3-carboxypropyl-5-fluorouracil; 5-Fluorouracil-1-propionic acid carboxamide; 69519-16-0
EINECS	Contact for details

Quality Control

Our 1-(3-Carboxypropylcarbamoyl)-5-Fluorouracil is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.