Description

1-Butylsulfonyl-5-Fluorouracil is a specialized fluorinated pyrimidine derivative, a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in developing novel therapeutic agents, particularly in oncology research, where its unique structure allows for targeted modifications. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antimetabolite drugs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluorouracil-based prodrugs and anticancer agents.
• Oncology Research: Used in biochemical and pharmacological research to study structure-activity relationships (SAR) of modified pyrimidines.
• Antimetabolite Development: Serves as a precursor for compounds designed to inhibit DNA synthesis in rapidly dividing cells.
• Bioconjugation Studies: The butylsulfonyl moiety can be utilized for conjugation with targeting ligands or other functional molecules.
• Chemical Biology Probes: Employed in the development of probes to study enzyme mechanisms, particularly thymidylate synthase inhibition.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for fluorinated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Butylsulfonyl-5-Fluorouracil
CAS No.	69207-34-7
Molecular Formula	C9H13FN2O4S
Molecular Weight	264.27 g/mol
Synonyms	5-Fluoro-1-(butylsulfonyl)uracil; 1-(Butylsulfonyl)-5-fluorouracil; 5-Fluoro-1-(butanesulfonyl)pyrimidine-2,4(1H,3H)-dione; 5-Fluorouracil-1-butanesulfonate; N1-Butylsulfonyl-5-fluorouracil; 1-Butanesulfonyl-5-fluorouracil; BS-5-FU; 5-FU-1-BS
EINECS	Contact for details

Quality Control

Our 1-Butylsulfonyl-5-Fluorouracil is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.