Description

2'-Fluoro-5-Bromo-1-β-D-Arabinofuranosylcytosine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a potential active pharmaceutical ingredient (API) for antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in the synthesis of novel nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced nucleoside analogs for antiviral and anticancer drug discovery.
• Antiviral Research: Investigated for its potential activity against DNA viruses, including herpesviruses and hepatitis B virus (HBV), due to its modified sugar and base moieties.
• Oncology Research: Studied for its potential as a cytotoxic agent or prodrug in cancer chemotherapy, leveraging its ability to interfere with DNA synthesis.
• Biochemical Tool: Used in molecular biology and enzymology studies to probe the mechanisms of DNA polymerases and nucleoside-metabolizing enzymes.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of related therapeutic agents.

Basic Information

Product Name	2'-Fluoro-5-Bromo-1-β-D-Arabinofuranosylcytosine
CAS No.	69123-93-9
Molecular Formula	C9H10BrFN3O5
Molecular Weight	339.10 g/mol
Synonyms	5-Bromo-2'-fluoro-ara-C; 2'-F-5-Br-araC; 5-Bromo-2'-fluoro-1-β-D-arabinofuranosylcytosine; 2'-Fluoro-5-bromo-arabinofuranosylcytosine; 5-Bromo-2'-deoxy-2'-fluorocytidine arabinoside; 69123-93-9; 2'-F-5-BrCyd (arabinofuranosyl)
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-5-Bromo-1-β-D-Arabinofuranosylcytosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.