Description

8-Hydroxyadenosine 5'-Triphosphate is a chemically modified nucleotide triphosphate analog of adenosine triphosphate (ATP). This compound is of significant value in biochemical research for studying nucleotide-dependent enzymes and probing cellular energy metabolism pathways. It is primarily utilized by researchers in pharmaceutical development, enzymology, and molecular biology for applications requiring modified nucleotide substrates.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate or inhibitor to investigate the specificity and catalytic mechanisms of ATP-dependent enzymes like kinases, ATPases, and polymerases.
• Biochemical Assay Development: Serves as a critical reagent in high-throughput screening (HTS) assays to identify modulators of nucleotide-binding proteins.
• Nucleic Acid Research: Potential use in studying RNA metabolism and processing enzymes that interact with modified nucleotides.
• Metabolic Pathway Analysis: A tool for probing alterations in cellular energy charge and nucleotide metabolism under various physiological or stress conditions.
• Structural Biology: Aiding in X-ray crystallography or NMR studies to determine protein-ligand complex structures with nucleotide analogs.
• Diagnostic Reagent Manufacturing: Can be incorporated into diagnostic kits for monitoring specific enzymatic activities relevant to disease states.

Basic Information

Product Name	8-Hydroxyadenosine 5'-Triphosphate
CAS No.	68745-44-8
Molecular Formula	C₁₀H₁₆N₅O₁₃P₃
Molecular Weight	523.17 g/mol
Synonyms	8-OH-ATP; 8-Hydroxy-ATP; 8-Oxo-adenosine triphosphate; 8-Oxo-ATP; Adenosine 5'-(tetrahydrogen triphosphate), 8-hydroxy-; 8-Hydroxyadenosine triphosphate; 8-HO-ATP
EINECS	Contact for details

Quality Control

Our 8-Hydroxyadenosine 5'-Triphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated at low temperature. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Tested in standard enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.