Description

Dehydroftorafur is a fluorinated pyrimidine derivative and a key pharmaceutical intermediate. This compound is of significant commercial interest due to its role in the synthesis of advanced chemotherapeutic agents and other biologically active molecules. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of fluorouracil (5-FU) prodrugs and related antineoplastic agents.
• Oncology Research: Used in preclinical and clinical research for developing novel chemotherapeutic treatments targeting various cancers.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce fluorinated pyrimidine scaffolds into complex molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Utilized in scaling up and optimizing manufacturing routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Dehydroftorafur
CAS No.	68723-23-9
Molecular Formula	C8H9FN2O3
Molecular Weight	200.17 g/mol
Synonyms	5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; 1-(Tetrahydro-2-furanyl)-5-fluorouracil; 5-Fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; FT-207 Impurity; Tegafur Impurity; Dehydro-Ftorafur; 1-(2-Tetrahydrofuryl)-5-fluorouracil
EINECS	Contact for details

Quality Control

Our Dehydroftorafur is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are provided and can be tailored to meet specific customer or regulatory standards, such as ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.