Description

Z-Gly-Pro-Amc CAS NO 68542-93-8 is a synthetic, fluorogenic peptide substrate specifically designed for the sensitive detection and kinetic analysis of dipeptidyl peptidase IV (DPP-IV) activity. This compound is a critical tool for researchers and developers in the life sciences, enabling precise biochemical assays and high-throughput screening. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic institutions focused on enzymology, metabolic disease research, and drug discovery.

Application

• Enzyme Activity Assays: Primary substrate for the fluorometric determination of DPP-IV (CD26) enzyme activity in biological samples.
• Drug Discovery & Screening: High-throughput screening (HTS) of potential DPP-IV inhibitors for the development of new therapeutics for type 2 diabetes and other conditions.
• Biochemical Research: Kinetic studies and characterization of DPP-IV enzyme mechanisms and substrate specificity in academic and industrial laboratories.
• Diagnostic Development: A key component in the formulation of clinical diagnostic kits for measuring DPP-IV levels in serum or plasma.
• Cell Biology Studies: Used to probe DPP-IV function and localization in live cells and tissue sections.
• Quality Control: Standard reagent for the quality assurance of recombinant DPP-IV enzyme production.

Basic Information

Product Name	Z-Gly-Pro-Amc
CAS No.	68542-93-8
Molecular Formula	C20H25N3O6
Molecular Weight	403.43 g/mol
Synonyms	Z-Gly-Pro-AMC; Z-Gly-Pro-7-amido-4-methylcoumarin; Benzyloxycarbonyl-Glycyl-Prolyl-7-amido-4-methylcoumarin; Cbz-Gly-Pro-AMC; DPP-IV Substrate; Gly-Pro-AMC derivative; CD26 Fluorogenic Substrate; H-Gly-Pro-AMC, N-Cbz protected
EINECS	Contact for details

Quality Control

Our Z-Gly-Pro-Amc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for sensitive research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol
Fluorogenic Properties	Excitation ~380 nm, Emission ~460 nm (upon cleavage)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.