Description

(2S)-2-[[4-[[(6S)-2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6- Yl]Methylamino]Benzoyl]Amino]Pentanedioic Acid is a high-purity, chemically defined folate analog and intermediate of significant interest in advanced pharmaceutical research and development. Its precise stereochemistry and functional groups make it a critical building block for synthesizing novel therapeutic agents and biochemical probes. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, metabolic disorders, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel folate receptor-targeting chemotherapeutic agents and drug conjugates.
• Biochemical Research: Used as a reference standard and building block in studying folate metabolism, enzyme inhibition, and one-carbon transfer pathways.
• Antifolate Drug Development: Serves as a core structure for developing next-generation dihydrofolate reductase (DHFR) and thymidylate synthase inhibitors.
• Diagnostic Agent Synthesis: Intermediate for creating labeled compounds (e.g., fluorinated, radiolabeled) for diagnostic imaging and biomarker studies.
• Academic Research: Employed in university and institutional labs for fundamental research in medicinal chemistry and chemical biology.

Basic Information

Product Name	(2S)-2-[[4-[[(6S)-2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6- Yl]Methylamino]Benzoyl]Amino]Pentanedioic Acid
CAS No.	68538-85-2
Molecular Formula	C₂₃H₂₅N₇O₇
Molecular Weight	511.49 g/mol
Synonyms	6-[(p-{[(2S)-2-Amino-1,5-dicarboxypentyl]carbamoyl}anilino)methyl]-2-amino-5-formyl-4-oxo-3,4,7,8-tetrahydro-6H-pteridine; 5-Formyl-5,6,7,8-tetrahydrofolic acid γ-glutamyl derivative; L-Glutamic acid, N-[4-[[(6S)-2-amino-5-formyl-3,4,7,8-tetrahydro-4-oxo-6H-pteridin-6-yl)methyl]amino]benzoyl]-; Folate analog intermediate; Tetrahydrofolate glutamyl derivative; 5-CHO-THF-Glu; (6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid γ-Glu
EINECS	Contact for details

Quality Control

Our (2S)-2-[[4-[[(6S)-2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6- Yl]Methylamino]Benzoyl]Amino]Pentanedioic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.