Description

Tos-Gly-Osu CAS NO 68385-26-2 is a highly reactive N-hydroxysuccinimide (NHS) ester derivative of tosyl-glycine, widely used as a key peptide coupling reagent and bioconjugation agent. Its primary value lies in its ability to efficiently activate carboxylic acids for amide bond formation under mild conditions, which is critical for synthesizing complex molecules and modifying biomolecules. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics research, and peptide synthesis, where precise and reliable conjugation chemistry is required.

Application

• Peptide Synthesis: Used as an activating agent for the carboxyl group of glycine and other amino acids in solid-phase and solution-phase peptide synthesis.
• Bioconjugation & Labeling: Facilitates the covalent attachment of peptides, proteins, or other molecules containing primary amine groups to various surfaces, probes, or carrier proteins.
• Cross-linking Agent: Employed in the preparation of cross-linked polymers or biomaterials where controlled amide bond formation is necessary.
• Intermediate for Active Pharmaceutical Ingredients (APIs): Serves as a crucial building block in the multi-step synthesis of complex drug candidates.
• Proteomics Research: Utilized in chemical proteomics for activity-based protein profiling and the study of protein-protein interactions.
• Material Science: Applied in the surface functionalization of nanomaterials and polymers to introduce specific bioactive motifs.

Basic Information

Product Name	Tos-Gly-Osu
CAS No.	68385-26-2
Molecular Formula	C14H16N2O6S
Molecular Weight	340.35 g/mol
Synonyms	N-[(p-Toluenesulfonyl)glycyl]oxy succinimide; N-(p-Tolylsulfonylglycyloxy)succinimide; Tosyl-Glycine N-Hydroxysuccinimide Ester; Tosylglycine NHS Ester; Glycine, N-[(4-methylphenyl)sulfonyl]-, 2,5-dioxo-1-pyrrolidinyl ester; TOS-GLY-OSU; TGL-OSU; N-Succinimidyl tosylglycinate
EINECS	Contact for details

Quality Control

Our Tos-Gly-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and loss on drying analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed in a desiccated environment to prevent hydrolysis and maintain reactivity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.