Description

Methotrexate-Polylysine CAS NO 68378-41-6 is a specialized pharmaceutical conjugate designed for targeted drug delivery, combining the potent chemotherapeutic agent methotrexate with a polylysine polymer backbone. This conjugation is engineered to enhance solubility, improve cellular uptake, and potentially reduce systemic toxicity compared to the free drug. It is a critical intermediate and research material for advanced drug development, particularly in oncology and autoimmune disease research. Pharmaceutical manufacturers and advanced research institutions require this high-purity conjugate for developing next-generation therapeutic formulations.

Application

• Primary research and development of targeted cancer therapeutics and drug delivery systems.
• Key intermediate in the synthesis of polymer-drug conjugates for enhanced pharmacokinetics.
• Investigational material for studying receptor-mediated endocytosis and cellular targeting mechanisms.
• Development of experimental treatments for autoimmune disorders such as rheumatoid arthritis and psoriasis.
• Formulation studies aimed at improving the solubility and stability of methotrexate-based products.
• Production of reference standards for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	Methotrexate-Polylysine
CAS No.	68378-41-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(L-lysine) conjugate with methotrexate; Methotrexate-PLL conjugate; MTX-Polylysine; MTX-PLL; Folic acid antagonist-polylysine conjugate; Polylysine-methotrexate; Antineoplastic agent-polymer conjugate; L-Lysine homopolymer methotrexate conjugate
EINECS	Contact for details

Quality Control

Our Methotrexate-Polylysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and conjugate integrity, aligning with research-grade and potential GMP starting material standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, degree of conjugation, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to prevent moisture uptake. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (Methotrexate Content)	≥ 95.0% (by HPLC)
Degree of Substitution	Contact for details
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Free Methotrexate	≤ 1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.