Description

2'-Deoxy-2'-Fluoroadenosine 5'-Diphosphate is a high-purity, modified nucleoside diphosphate essential for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and metabolic intermediate in the study of nucleic acid chemistry, enzyme mechanisms, and antiviral drug pathways. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in nucleotide analog synthesis and molecular biology applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for polymerases and kinases involved in nucleotide metabolism.
• Antiviral Drug Development: Serves as a key intermediate or reference standard in the synthesis and evaluation of nucleoside analog prodrugs targeting viral replication.
• Diagnostic Assay Manufacturing: Employed in the formulation of specialized reagents for molecular diagnostics and high-throughput screening platforms.
• Enzymology Studies: Acts as a crucial cofactor or analog in mechanistic studies of ATP-dependent enzymes and signal transduction pathways.
• Nucleotide Analog Synthesis: Provides a fluorinated backbone for creating novel modified nucleotides with altered binding properties and metabolic stability.
• Metabolic Pathway Analysis: Used as a tracer or standard in LC-MS/MS and HPLC-based assays to study cellular nucleotide pools and drug incorporation.

Basic Information

Product Name	2'-Deoxy-2'-Fluoroadenosine 5'-Diphosphate
CAS No.	68357-16-4
Molecular Formula	C10H14FN5O9P2
Molecular Weight	429.19 g/mol
Synonyms	2'-Deoxy-2'-fluoroadenosine-5'-diphosphate; 2'-F-dADP; 2'-Fluoro-2'-deoxyadenosine 5'-diphosphate; 9-[(2R,3R,4S,5R)-5-[(Hydroxy{[(hydroxy{[(hydroxy)phosphinato]oxy})phosphoryl]oxy})phosphoryl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-aminopurine; Adenosine, 2'-deoxy-2'-fluoro-, 5'-(trihydrogen diphosphate); 2'-F-ADP; 2'-Fluoro-dADP; 2'-Deoxy-2'-fluoroadenosine diphosphate
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoroadenosine 5'-Diphosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide Certificates of Analysis (COA) with detailed chromatograms and spectral data to ensure traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.