Description

(R/S)-n-Deacetyl Colchiceine is a key intermediate and reference standard derived from the natural alkaloid colchicine. This compound is of significant interest in pharmaceutical research and development, particularly for its role in studying anti-inflammatory and anti-mitotic mechanisms. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel therapeutics and analytical method development.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of novel colchicine derivatives and analogs for therapeutic applications.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical laboratories to ensure product purity and identity.
• Biochemical Research: Employed in life science research to study tubulin polymerization inhibition, cell cycle arrest, and anti-inflammatory pathways.
• Metabolite Studies: Serves as a reference compound for investigating the metabolism and pharmacokinetics of colchicine and related substances.
• Process Chemistry: Utilized in scale-up and optimization studies for the production of high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(R/S)-n-Deacetyl Colchiceine
CAS No.	68296-64-0
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	N-Deacetylcolchiceine; Colchiceine; 3-Demethylcolchicine; 10-Demethylcolchicine; N-Desacetylcolchicine; (7S)-3-Demethyl-10-demethoxycolchicine; 3,10-Didesmethylcolchicine; Colchicein
EINECS	Contact for details

Quality Control

Our (R/S)-n-Deacetyl Colchiceine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.