Description

4-Aminoantipyrine-D3 (Aa-D3) is a deuterium-labeled analog of the important analytical reagent 4-Aminoantipyrine. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses, where it serves as an internal standard. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, environmental, and clinical diagnostics sectors for method development and validation.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of antipyrine and its metabolites in pharmacokinetic studies.
• Essential for isotope dilution mass spectrometry (IDMS) methods, providing high-precision measurements in bioanalytical and environmental analysis.
• Applied in drug metabolism and disposition (DMPK) research to track and quantify the parent drug and its biotransformation products.
• Facilitates clinical research involving therapeutic drug monitoring and studies on enzyme activity (e.g., cytochrome P450 phenotyping).
• Supports forensic and toxicological analysis for the accurate detection of specific compounds in complex biological matrices.
• Enables environmental monitoring programs targeting phenolic compounds when used in derivative-based detection methods.

Basic Information

Product Name	4-Aminoantipyrine-D3 (Aa-D3)
CAS No.	68229-55-0
Molecular Formula	C11H10D3N3O
Molecular Weight	203.26 g/mol
Synonyms	4-Aminoantipyrine-d3; 4-AAP-d3; 1,5-Dimethyl-2-phenyl-4-(amino-d3)-3-pyrazolone; 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one-d3; Deuterated 4-Aminoantipyrine; Ampyrone-d3; 4-Aminophenazone-d3; 4-Aminophenazon-d3
EINECS	Contact for details

Quality Control

Our 4-Aminoantipyrine-D3 is manufactured under controlled conditions to ensure high isotopic purity and chemical integrity, essential for its role as a quantitative internal standard. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm isotopic enrichment (typically ≥98 atom % D) and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.