Description

Substance P (1-7) CAS NO 68060-49-1 is a specific heptapeptide fragment of the full neuropeptide Substance P, representing the N-terminal sequence (Arg-Pro-Lys-Pro-Gln-Gln-Phe). This fragment is a critical research tool for studying the structure-activity relationships and selective biological functions of Substance P, particularly those mediated by its N-terminal domain. It is essential for neuroscientists, pharmacologists, and biochemical researchers investigating neuroinflammation, pain signaling, and receptor subtype specificity. The compound enables targeted studies without the full spectrum of activity associated with the complete undecapeptide.

Application

• Neuroscience Research: Used as a selective agonist/antagonist to probe the functions of the N-terminal domain of Substance P in central and peripheral nervous systems.
• Pharmacological Studies: Critical for mapping receptor binding sites and understanding the interaction with neurokinin-1 (NK1) receptor subtypes and other putative receptors.
• Biochemical Assay Development: Serves as a reference standard and key reagent in ELISA, RIA, and other immunoassays designed to detect Substance P fragments.
• Pain and Inflammation Models: Applied in vitro and in vivo to study the role of Substance P fragments in nociception, neurogenic inflammation, and migraine pathways.
• Drug Discovery: Used as a lead compound or structural template for designing novel peptide-based therapeutics targeting neuropeptide pathways.
• Cell Signaling Research: Investigates intracellular signaling cascades (e.g., involving Ca2+ mobilization, PKC activation) initiated by truncated neuropeptides.

Basic Information

Product Name	Substance P (1-7)
CAS No.	68060-49-1
Molecular Formula	C41H62N12O9
Molecular Weight	867.0 g/mol
Synonyms	Substance P Fragment 1-7; Arg-Pro-Lys-Pro-Gln-Gln-Phe; SP(1-7); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH; Neurokinin P (1-7); Substance P (1-7) amide (if applicable); [Arg1, Pro2, Lys3, Pro4, Gln5, Gln6, Phe7]-Substance P
EINECS	Contact for details

Quality Control

Our Substance P (1-7) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Solubility	Soluble in water, dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.