Description

(2S,4S)-2-Amino-4-Methyl-5-Hexenoic Acid CAS NO 68013-07-0 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry and terminal alkene functionality. This compound is a critical chiral building block in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate unique structural features, influencing peptide conformation and biological activity.
• Medicinal Chemistry Research: Serves as a constrained amino acid analog in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation & Probe Development: The reactive alkene group enables site-specific modifications, such as thiol-ene click chemistry, for labeling proteins or creating diagnostic probes.
• Asymmetric Synthesis Catalyst Ligand: Can be utilized in the development of chiral ligands or organocatalysts for enantioselective transformations.
• Fine Chemical Production: An intermediate in the multi-step synthesis of complex natural products and specialty chemicals.

Basic Information

Product Name	(2S,4S)-2-Amino-4-Methyl-5-Hexenoic Acid
CAS No.	68013-07-0
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(2S,4S)-2-Amino-4-methyl-5-hexenoic acid; (2S,4S)-4-Methyl-2-amino-5-hexenoic acid; (2S,4S)-2-Amino-4-methylhex-5-enoic acid; L-2-Amino-4-methyl-5-hexenoic acid (specifying stereochemistry); 2-Amino-4-methyl-5-hexenoic acid (mixed isomers); AMHA (abbreviation); A non-proteinogenic amino acid derivative.
EINECS	Contact for details

Quality Control

Our (2S,4S)-2-Amino-4-Methyl-5-Hexenoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and stereochemical purity suitable for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.