Description

L-Tetrahydrozoline is a potent imidazoline derivative with significant pharmacological activity. This compound is valued for its selective α-adrenergic agonist properties, making it a key intermediate in the synthesis of high-value pharmaceutical actives. It is primarily required by manufacturers in the pharmaceutical and advanced fine chemical sectors for developing ophthalmic and nasal decongestant formulations. Consistent quality and reliable supply are critical for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of tetrahydrozoline hydrochloride, a widely used vasoconstrictor.
• Ophthalmic Solutions: Key precursor for active pharmaceutical ingredients (APIs) in eye drops designed to relieve redness and irritation.
• Nasal Decongestants: Used in the manufacturing of APIs for nasal sprays that reduce swelling in nasal passages.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry research for new adrenergic compounds.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized imidazoline-based molecules.

Basic Information

Product Name	L-Tetrahydrozoline
CAS No.	67731-53-7
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	(-)-Tetrahydrozoline; L-(-)-Tetrahydrozoline; (S)-Tetrahydrozoline; (4S)-2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazole; Levotetrahydrozoline; Tetrahydrozoline Base; 1,2,3,4-Tetrahydro-1-naphthylimidazoline
EINECS	Contact for details

Quality Control

Our L-Tetrahydrozoline is manufactured under strict quality management systems to ensure it meets the high-purity requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to confirm identity, potency, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.