Description

2-(1H-Benzotriazol-1-Yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate is a highly efficient peptide coupling reagent widely used in solid-phase and solution-phase peptide synthesis. Its primary value lies in its ability to minimize racemization and accelerate amide bond formation, leading to higher yields and purer products. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable and high-performance reagents for complex organic synthesis.

Application

• Primary reagent for peptide coupling in solid-phase peptide synthesis (SPPS).
• Facilitates amide bond formation in the synthesis of complex organic molecules and natural products.
• Used in the preparation of peptidomimetics and other bioactive compounds for drug discovery.
• Employed in solution-phase peptide synthesis for the production of specific peptide sequences.
• Acts as a condensing agent in the synthesis of esters and other carboxylic acid derivatives.
• Critical for research and development in pharmaceutical intermediates and active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	2-(1H-Benzotriazol-1-Yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate
CAS No.	67654-71-1
Molecular Formula	C11H16F6N6OP
Molecular Weight	384.25 g/mol
Synonyms	HBTU; Hexafluorophosphate Benzotriazole Tetramethyl Uronium; 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; Benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate; Coupling Reagent HBTU; CAS 67654-71-1
EINECS	Contact for details

Quality Control

Our 2-(1H-Benzotriazol-1-Yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, assay, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical-grade reagents and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in polar aprotic solvents (DMF, DMSO, Acetonitrile)
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.