Description

21-Acetyl-6β-Fluorotriamcinolone Acetonide CAS NO 67438-37-3 is a fluorinated synthetic corticosteroid derivative, serving as a key pharmaceutical intermediate. Its primary value lies in enabling the synthesis of advanced topical anti-inflammatory and immunosuppressive agents. This high-purity compound is essential for research and development laboratories and manufacturers within the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of potent topical corticosteroids and related steroid-based APIs.
• Research & Development: Used in medicinal chemistry for developing new anti-inflammatory and immunomodulatory drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Dermatological Formulations: Key building block for active ingredients used in creams, ointments, and lotions for treating skin conditions like eczema and psoriasis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid drugs.

Basic Information

Product Name	21-Acetyl-6β-Fluorotriamcinolone Acetonide
CAS No.	67438-37-3
Molecular Formula	C₂₆H₃₃FO₇
Molecular Weight	476.54 g/mol
Synonyms	21-Acetyl-6β-fluorotriamcinolone acetonide; 6β-Fluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione 21-acetate; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate; Fluocinolone Acetonide Acetate; 6β-Fluorotriamcinolone Acetonide 21-Acetate; 21-O-Acetyl-6β-fluorotriamcinolone acetonide
EINECS	Contact for details

Quality Control

Our 21-Acetyl-6β-Fluorotriamcinolone Acetonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Avoid exposure to excessive heat and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.