Description

Tosyl-L-Leucine CAS NO 67368-40-5 is a protected amino acid derivative where the amine group of L-leucine is blocked by a tosyl group. This compound is a crucial building block in peptide synthesis and organic chemistry, providing a versatile intermediate for the controlled formation of peptide bonds. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutic peptides and complex organic molecules.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis for constructing complex peptide sequences.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of peptides to other biomolecules or surfaces.
• Fine Chemical Production: An important precursor in the synthesis of specialized amino acid derivatives and chiral auxiliaries.
• Biochemical Research: Employed in studies of enzyme mechanisms and protein structure-function relationships.
• Cosmetic Peptides: Can be utilized in the development of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	Tosyl-L-Leucine
CAS No.	67368-40-5
Molecular Formula	C13H19NO4S
Molecular Weight	285.36 g/mol
Synonyms	L-Leucine, N-[(4-methylphenyl)sulfonyl]-; N-p-Tosyl-L-leucine; N-Tosyl-L-leucine; (2S)-2-[(4-Methylphenyl)sulfonylamino]-4-methylpentanoic acid; Tosyl-Leucine-OH; Tle-OH; p-Toluenesulfonyl-L-leucine; Leucine, N-tosyl-
EINECS	Contact for details

Quality Control

Our Tosyl-L-Leucine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.