Description

Guanosine Diphosphate 2-Deoxy-2-Fluoromannose Ester is a specialized nucleotide-sugar conjugate, a crucial biochemical intermediate for the study and manipulation of glycosylation pathways. This compound matters for its role as a high-energy donor substrate in enzymatic synthesis, enabling the precise incorporation of fluorinated sugars into target molecules. It is primarily needed by researchers and manufacturers in pharmaceutical development, glycobiology research, and the production of complex oligosaccharides for therapeutic and diagnostic applications.

Application

• Enzymatic Glycosylation Studies: Acts as a key donor substrate for glycosyltransferases in the synthesis of fluorinated glycoconjugates.
• Glycobiology Research: Used to probe enzyme mechanisms, study carbohydrate-protein interactions, and investigate metabolic pathways involving fluorinated sugars.
• Pharmaceutical R&D: Serves as a building block for the development of novel glycan-based therapeutics, vaccines, and diagnostic agents.
• Chemical Biology Tool Development: Employed in the creation of activity-based probes and metabolic labeling agents to track glycosylation in living systems.
• Biocatalyst Development: Used as a substrate to assay and engineer glycosyltransferases for improved activity or altered specificity.
• Oligosaccharide Synthesis: A critical reagent in chemo-enzymatic strategies for the controlled, stepwise assembly of complex, fluorinated oligosaccharides.

Basic Information

Product Name	Guanosine Diphosphate 2-Deoxy-2-Fluoromannose Ester
CAS No.	67341-46-2
Molecular Formula	C16H23FN5O15P2
Molecular Weight	605.32 g/mol
Synonyms	GDP-2-Deoxy-2-fluoro-D-mannose; Guanosine 5'-(trihydrogen diphosphate) 2-deoxy-2-fluoro-α-D-mannopyranosyl ester; GDP-2FMan; 2-Deoxy-2-fluoro-D-mannose GDP ester; 2-Fluoro-2-deoxy-D-mannose guanosine diphosphate ester; Guanosine diphosphate 2-fluoro-2-deoxy-mannose; α-D-Manp2F-GDP
EINECS	Contact for details

Quality Control

Our Guanosine Diphosphate 2-Deoxy-2-Fluoromannose Ester is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All materials are subjected to comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.