Description

Gly-Pro-Mca Tosylate is a specialized fluorogenic peptide substrate designed for the sensitive detection and study of protease activity. This compound is of significant value in biochemical and pharmaceutical research for its role in developing high-throughput screening assays and enzyme kinetic studies. It is primarily needed by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic reagent sectors.

Application

• Protease Enzyme Assays: A key fluorogenic substrate for the continuous, real-time monitoring of dipeptidyl peptidase (DPP) activity, particularly DPP-IV.
• High-Throughput Screening (HTS): Used in pharmaceutical discovery to identify and characterize potential inhibitors of target proteases.
• Biochemical Research: Essential for studying enzyme kinetics, specificity, and catalytic mechanisms in vitro.
• Diagnostic Development: Serves as a critical component in the development of clinical diagnostic tests for conditions linked to specific protease levels.
• Quality Control in Biologics: Employed to monitor protease activity during the production and purification of biopharmaceuticals.
• Academic Research: A fundamental tool in university and institutional labs for cell biology and proteolysis pathway studies.

Basic Information

Product Name	Gly-Pro-Mca Tosylate
CAS No.	67341-42-8
Molecular Formula	C₂₆H₂₉N₃O₇S
Molecular Weight	527.59 g/mol
Synonyms	Gly-Pro-7-Amido-4-methylcoumarin Tosylate; Glycyl-L-prolyl 4-methyl-7-coumarylamide p-toluenesulfonate; H-Gly-Pro-AMC.Tos; DPP-IV Substrate Gly-Pro-AMC Tosylate; Gly-Pro-AMC p-Toluenesulfonate; Succinyl-Gly-Pro-AMC (related); Fluorogenic Peptide Substrate for DPP-IV
EINECS	Contact for details

Quality Control

Our Gly-Pro-Mca Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Fluorimetric Performance	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.