Description

1,2-Di[(Cis)-9-Octadecenoyl]-Sn-Glycerol-3-Phospho-[1-Rac-Glycerol] Sodium Salt is a high-purity synthetic phospholipid, specifically a sodium salt of phosphatidylglycerol (PG) with defined oleoyl fatty acid chains. This compound is critical for creating stable, biocompatible lipid membranes and vesicles, offering superior consistency compared to natural extracts. It is an essential raw material for researchers and manufacturers in advanced pharmaceutical formulations, particularly in liposome and lipid nanoparticle (LNP) drug delivery systems for vaccines, mRNA therapies, and targeted cancer treatments.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key excipient for constructing stable, anionic lipid bilayers in drug delivery carriers for nucleic acids (mRNA, siRNA), small molecules, and proteins.
• Pulmonary Surfactant Mimetics: Used in research and development of synthetic lung surfactants for treating respiratory distress syndrome (RDS).
• Biomembrane & Model System Studies: Essential for creating defined phospholipid bilayers in biophysical research to study membrane protein interactions, permeability, and fusion.
• Diagnostic Reagent Preparation: Employed in the formulation of lipid-based components for diagnostic assays and imaging contrast agents.
• Cosmetic & Dermal Delivery Systems: Acts as a high-performance emulsifier and penetration enhancer in advanced cosmetic formulations for targeted skin delivery.
• Cell Culture & Biotechnology: Used as a supplement in specialized cell culture media and in the reconstitution of membrane proteins.

Basic Information

Item	Details
Product Name	1,2-Di[(Cis)-9-Octadecenoyl]-Sn-Glycerol-3-Phospho-[1-Rac-Glycerol] Sodium Salt
CAS No.	67254-28-8
Molecular Formula	C44H82NaO10P
Molecular Weight	801.09 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt; DOPG-Na; 1,2-Dioleoyl-sn-glycero-3-phosphoglycerol sodium salt; PG(18:1/18:1) sodium salt; Phosphatidylglycerol (18:1) sodium salt; Sodium 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol); 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-sn-glycero-3-phosphoglycerol sodium salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and fatty acid profile confirmation, to ensure it meets the stringent requirements for pharmaceutical and life science research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Under these conditions, the product is typically stable for at least 24 months. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White or off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Fatty Acid Composition (GC)	≥ 95% Oleic acid (C18:1)
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Biological Test (Endotoxin)	< 10 EU/mg (upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.