Description

Uridine Phosphate-β-Thiophosphate Glucose is a chemically modified nucleotide sugar analog of significant interest in biochemical research and pharmaceutical development. This compound serves as a crucial tool molecule for studying enzymatic pathways, particularly those involving glycosyltransferases and nucleotide sugar metabolism. It is primarily utilized by researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on metabolic disorders, antiviral drug discovery, and nucleotide-based therapeutics.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of glycosyltransferases and other nucleotide sugar-utilizing enzymes.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and screening of novel antiviral and anticancer nucleotide analogs.
• Metabolic Pathway Analysis: Employed in tracer studies to investigate sugar nucleotide metabolism and related biosynthetic pathways in cells.
• Enzyme Mechanism Studies: Utilized to probe the catalytic mechanisms of enzymes due to the sulfur substitution in the phosphate group, which can resist hydrolysis.
• Diagnostic Reagent Manufacturing: Potential use as a specialized component in enzymatic diagnostic kits for clinical testing.

Basic Information

Product Name	Uridine Phosphate-β-Thiophosphate Glucose
CAS No.	67246-26-8
Molecular Formula	C15H23N2O16P2S
Molecular Weight	581.34 g/mol
Synonyms	UDP-α-D-glucose-β-thiophosphate; Uridine 5'-(α-D-glucopyranosyl diphosphate) β-thiophosphate; UDP-Glc β-thiophosphate; Uridine diphosphoglucose β-thiophosphate; Thiophosphoryl-UDP-glucose; UDP-α-D-glucose thiophosphate; Uridine 5'-diphospho-α-D-glucose, β-thiophosphate derivative
EINECS	Contact for details

Quality Control

Our Uridine Phosphate-β-Thiophosphate Glucose is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material for qualification under GMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.