Description

Methotrexate-γ-Methylamide CAS NO 67036-48-0 is a chemically modified derivative of the antifolate agent methotrexate, designed for advanced research and development applications. This compound is of significant interest for its potential role in exploring novel therapeutic pathways and biochemical mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and investigation of novel antifolate compounds and targeted therapies.
• Biochemical Research: Used in enzymatic studies, particularly those involving dihydrofolate reductase (DHFR) inhibition, to understand cellular metabolism and proliferation pathways.
• Academic Studies: Employed in university and institutional laboratories for chemical biology projects and the development of new analytical methods.
• Preclinical Studies: Investigated for its pharmacokinetic and pharmacodynamic properties in non-clinical models to assess therapeutic potential.
• Process Chemistry: Acts as a building block or impurity standard in the development and scale-up of complex active pharmaceutical ingredient (API) manufacturing processes.

Basic Information

Product Name	Methotrexate-γ-Methylamide
CAS No.	67036-48-0
Molecular Formula	C21H24N8O4
Molecular Weight	452.47 g/mol
Synonyms	N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid γ-methylamide; MTX-γ-Methylamide; Methotrexate γ-Methylamide; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 5-methylamide; Amethopterin γ-methylamide
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-Methylamide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.