Description

Pumiliotoxin B CAS NO 67016-65-3 is a potent alkaloid neurotoxin originally isolated from the skin of poison dart frogs (*Dendrobatidae*). This compound is of significant interest in neuroscience and pharmacological research due to its specific activity on sodium channels, making it a valuable tool for studying neuronal excitability and signal transduction. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neurobiology, toxicology, and the development of novel therapeutic agents or analytical standards.

Application

• Neuroscience Research: As a selective pharmacological tool for investigating voltage-gated sodium channel function and modulation.
• Toxicology Studies: Used as a reference standard in the study of natural neurotoxins and their mechanisms of action.
• Drug Discovery: Serves as a lead compound or molecular probe in the development of new analgesics, anesthetics, or neuroprotective agents.
• Analytical Standard: Provides a high-purity reference material for method development and quality control in analytical laboratories (e.g., HPLC, LC-MS).
• Biochemical Assays: Employed in in vitro assays to characterize ion channel activity and screen for potential channel blockers or modulators.
• Academic Research: Fundamental studies in chemical ecology, evolutionary biology, and natural product chemistry.

Basic Information

Product Name	Pumiliotoxin B
CAS No.	67016-65-3
Molecular Formula	C19H31NO2
Molecular Weight	305.46 g/mol
Synonyms	(+)-Pumiliotoxin B; PTX-B; Allopumiliotoxin 267A; 8-Hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo[4.3.0]nonane; 1-Azabicyclo[4.3.0]nonane, 8-hydroxy-8-methyl-6-(2-methylhexylidene)-, (6Z)-
EINECS	Contact for details

Quality Control

Our Pumiliotoxin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance as a critical tool in your scientific investigations.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.