Description

Apraclonidine is a selective α-2 adrenergic receptor agonist, a potent and well-characterized pharmaceutical active ingredient. It is primarily valued for its ability to reduce intraocular pressure, making it a critical component in ophthalmic solutions. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for glaucoma and for use in diagnostic procedures. Apraclonidine CAS NO 66711-21-5 is supplied under stringent quality controls to ensure reliability for sensitive formulation work.

Application

• Ophthalmic Pharmaceutical Formulations: Primary active ingredient in prescription eye drops for the management of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
• Diagnostic Agent: Used in pharmacological testing and diagnostic procedures, such as the apraclonidine suppression test, to help diagnose conditions like Horner's syndrome.
• Research & Development: Serves as a key reference standard and biochemical tool in neuroscience and pharmacological research studying α-2 adrenergic receptor pathways.
• API Synthesis: Used as a high-purity starting material or intermediate in the synthesis of more complex pharmaceutical compounds within the adrenergic agent class.
• Veterinary Medicine: Potential application in veterinary ophthalmic preparations for managing ocular pressure in animals.

Basic Information

Product Name	Apraclonidine
CAS No.	66711-21-5
Molecular Formula	C9H10Cl2N4
Molecular Weight	245.11 g/mol
Synonyms	p-Aminoclonidine; 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine; AL-02145; Iopidine (brand name); ALO 2145; 4-Aminoclonidine; NSC-351120; UK-14,304-18
EINECS	Contact for details

Quality Control

Our Apraclonidine is manufactured and tested to meet the exacting standards required for pharmaceutical application. Quality assurance includes rigorous analytical testing for identity, purity, and impurities. We can supply material compliant with various pharmacopeial monographs, and a comprehensive Certificate of Analysis (COA) is provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.