Description

5-Hydroxy Tryptophol-D4 is a stable isotope-labeled analog of the endogenous metabolite 5-hydroxytryptophol, where four hydrogen atoms are replaced by deuterium. This compound is a critical tool for quantitative mass spectrometry, enabling precise and accurate measurement of its endogenous counterpart in complex biological matrices. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for advanced analytical applications.

Application

• Internal Standard for LC-MS/MS: Serves as a deuterated internal standard for the precise quantification of 5-hydroxytryptophol in bioanalytical methods, enhancing accuracy and reproducibility.
• Metabolomics Research: Used in targeted metabolomics studies to investigate serotonin and melatonin metabolic pathways, aiding in the understanding of neurological and endocrine disorders.
• Biomarker Assay Development: Essential for developing and validating high-sensitivity clinical assays for biomarkers related to carcinoid tumors and other neuroendocrine conditions.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Employed in drug development to track the metabolism of serotonergic agents and their impact on related biochemical pathways.
• Quality Control Reference Material: Acts as a certified reference material (CRM) for calibrating instruments and verifying analytical procedures in regulated laboratory environments.

Basic Information

Product Name	5-Hydroxy Tryptophol-D4
CAS No.	66640-87-7
Molecular Formula	C10H9D4NO2
Molecular Weight	183.23 g/mol (for deuterated form)
Synonyms	5-Hydroxytryptophol-d4; 3-(2-Aminoethyl)-5-hydroxyindole-2,2,3,3-d4; 5-HTOL-d4; 5-Hydroxyindole-3-ethanol-d4; 1H-Indol-5-ol, 3-(2-aminoethyl)-2,2,3,3-tetradeuterio-; Deuterated 5-Hydroxytryptophol; 5-Hydroxytryptophol (tetradeuterated)
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Tryptophol-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity, and HPLC for chemical purity assessment. We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results for chemical purity, isotopic enrichment, and residual solvents, ensuring traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.