Description

2'-o-Methylisoleiocin is a specialized nucleoside analog with a modified ribose moiety, identified by CAS NO 66516-95-8. This compound is valued for its role as a key intermediate and building block in advanced oligonucleotide synthesis, enabling precise control over genetic material properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA therapeutics, and other cutting-edge nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: Serves as a critical phosphoramidite monomer for the solid-phase synthesis of modified RNA strands.
• Antisense Therapy Research: Used in the development of oligonucleotides designed to modulate gene expression for therapeutic targets.
• siRNA and miRNA Development: Acts as a building block to enhance the stability, specificity, and pharmacokinetic profile of RNA interference agents.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to improve hybridization stability and detection sensitivity.
• Biochemical Research: Employed in studies investigating RNA structure, function, and protein-RNA interactions.
• Pharmaceutical Intermediates: Functions as a high-purity intermediate in the cGMP-compliant production of active pharmaceutical ingredients (APIs) for nucleic acid drugs.

Basic Information

Product Name	2'-o-Methylisoleiocin
CAS No.	66516-95-8
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	2'-O-Methylisoleiocin; 2'-O-Methyl-5-methyluridine; 5-Methyl-2'-O-methyluridine; 2'-O-Methyl-5-methyl-2'-deoxyuridine; 1-(2-O-Methyl-β-D-ribofuranosyl)-5-methyluracil; 5-Methyl-2'-O-methyl-2'-deoxyuridine; 2'-OMe-5-MeU; 2'-O-Methyl-5-methyluridine (isoleiocin analog)
EINECS	Contact for details

Quality Control

Our 2'-o-Methylisoleiocin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.