Description

(6S,8S,9R,10S,11S,13R,14S,17S)-17-Acetyl-6,9-Difluoro-11-Hydroxy-10,13-Dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one is a high-purity, fluorinated steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for creating novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated corticosteroids and other steroidal drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory and immunosuppressive agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Investigated for its interaction with steroid hormone receptors due to its specific fluorination pattern.

Basic Information

Product Name	(6S,8S,9R,10S,11S,13R,14S,17S)-17-Acetyl-6,9-Difluoro-11-Hydroxy-10,13-Dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS No.	66211-95-8
Molecular Formula	C21H26F2O3
Molecular Weight	364.43 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-Acetonide; 6α,9α-Difluoroprednisolone 17-Acetonide; Fluocinolone Acetonide Related Compound; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-(1-oxoethyl)-androsta-1,4-diene-3-one; Difluoroprednisolone Acetonide; 66211-95-8; 6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxoethyl)-androsta-1,4-dien-17-yl
EINECS	Contact for details

Quality Control

Our (6S,8S,9R,10S,11S,13R,14S,17S)-17-Acetyl-6,9-Difluoro-11-Hydroxy-10,13-Dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and should be handled with appropriate precautions for materials containing fluoride/strong alkali functional groups.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.