Description

Dolichol Pyrophosphate Man(1-4)-Glcnac(1-4)Glcnac is a critical, high-purity glycolipid intermediate essential for N-linked protein glycosylation pathways. This compound matters as a precisely defined substrate for studying and manipulating oligosaccharyltransferase activity, a key step in glycoprotein biosynthesis. Researchers and manufacturers in biopharmaceutical development, enzymology, and glycobiology require this material for producing homogeneous glycoproteins, developing glycosylation inhibitors, and advancing therapeutic protein engineering.

Application

• Biochemical Research: Essential substrate for in vitro studies of the oligosaccharyltransferase (OST) enzyme complex and N-glycosylation mechanisms.
• Glycoprotein Synthesis: Used as a donor substrate in chemoenzymatic synthesis to create structurally defined, homogeneous N-linked glycoproteins.
• Enzyme Assay Development: Critical component in high-throughput screening assays to identify novel inhibitors or modulators of protein glycosylation.
• Therapeutic Protein Engineering: Enables the production of recombinant proteins with humanized or optimized glycosylation patterns for improved efficacy and stability.
• Diagnostic Tool Development: Serves as a standard or key reagent in diagnostic kits targeting glycosylation-related disorders.
• Academic & Institutional Research: Fundamental tool for laboratories investigating congenital disorders of glycosylation (CDG), cancer biomarkers, and viral pathogenesis.

Basic Information

Product Name	Dolichol Pyrophosphate Man(1-4)-Glcnac(1-4)Glcnac
CAS No.	66198-45-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dol-PP-Man(α1-4)GlcNAc(β1-4)GlcNAc; Dolichyl Diphosphoryl Tetrasaccharide; Dol-PP-(GlcNAc)₂-Man; Lipid-linked Oligosaccharide (LLO) Intermediate; N,N'-Diacetylchitobiosyl Diphosphodolichol Mannosyl Derivative; Dol-PP-GlcNAc₂-Man₁; DPM1 Substrate
EINECS	Contact for details

Quality Control

Our Dolichol Pyrophosphate Man(1-4)-Glcnac(1-4)Glcnac is produced and handled under stringent conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, MS, and NMR, to verify structural identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid/film
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.