Description

Cyproheptadine Glucuronide is a key metabolite and reference standard of the antihistamine drug cyproheptadine. This high-purity compound is essential for pharmaceutical research, development, and quality control processes, providing a critical benchmark for analytical studies. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of cyproheptadine and its metabolites in biological matrices.
• Drug Metabolism Studies (DMPK): Used in in vitro and in vivo studies to understand the metabolic pathway and glucuronidation of cyproheptadine.
• Bioanalytical Method Development & Validation: Critical for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic analysis.
• Impurity Profiling: Employed as an impurity marker in the stability testing and quality control of cyproheptadine active pharmaceutical ingredient (API) and finished dosage forms.
• Clinical Research: Used in studies investigating the safety, efficacy, and metabolic profile of cyproheptadine in human subjects.
• Toxicological Research: Applied in forensic and clinical toxicology to confirm the presence of cyproheptadine use or exposure.

Basic Information

Product Name	Cyproheptadine Glucuronide
CAS No.	66167-97-3
Molecular Formula	C₂₈H₃₃ClN₂O₇
Molecular Weight	545.02 g/mol
Synonyms	1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine Glucuronide; Cyproheptadine D-Glucuronide; Periactin Glucuronide; NSC 113939; Cyproheptadine Glucuronide Conjugate; Cyproheptadine β-D-Glucuronide; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Glucuronide
EINECS	Contact for details

Quality Control

Our Cyproheptadine Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified purity criteria, typically ≥95% to ≥98% by HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (HPLC)	≥95.0% - ≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.