Description

n-Acetylcolchinol, Methyl Ether is a semi-synthetic derivative of the natural alkaloid colchicine, characterized by its modified acetyl and methoxy functional groups. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or reference standard for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of anti-inflammatory and anti-cancer compounds, as well as in biochemical studies targeting tubulin polymerization.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel colchicine derivatives with potential therapeutic applications.
• Biochemical Research: Used as a reference standard or probe in studies investigating tubulin dynamics and microtubule disruption mechanisms.
• Anti-inflammatory Agent Development: Acts as a precursor for compounds being evaluated for the treatment of gout and other inflammatory conditions.
• Oncology Research: Investigated for its potential as a lead compound or intermediate in the development of anti-mitotic and anti-cancer drugs.
• Analytical Reference Standard: Employed in quality control laboratories for the identification and quantification of related substances via HPLC or LC-MS methods.

Basic Information

Product Name	n-Acetylcolchinol, Methyl Ether
CAS No.	65967-01-3
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	N-Acetylcolchinol methyl ether; Colchinol, N-acetyl-, methyl ether; 3-(Acetylamino)-10-methoxy-6,7-dihydro-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one; N-Acetyl-N-deacetylcolchicine methyl ether; Deacetylcolchicine methyl ether, N-acetyl-; Colchicine derivative 65967-01-3
EINECS	Contact for details

Quality Control

Our n-Acetylcolchinol, Methyl Ether is produced under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistency. Each batch is characterized using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.