Description

Tegafur is a fluoropyrimidine derivative and a prodrug of the chemotherapeutic agent 5-fluorouracil (5-FU). This compound is valued for its role in targeted cancer therapy, offering a mechanism for the controlled release of the active metabolite to improve therapeutic efficacy and manage side effects. It is a critical intermediate and active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing oncology treatments.

Application

• Oncological Pharmaceutical Manufacturing: Primary use as an Active Pharmaceutical Ingredient (API) in oral and injectable formulations for cancer therapy.
• Combination Therapy Drugs: Key component in fixed-dose combination products, such as those with uracil (e.g., UFT) or gimeracil/oteracil (e.g., S-1), for enhanced efficacy.
• Clinical Research & Development: Serves as a reference standard and building block in preclinical and clinical studies for novel anti-cancer agents and drug delivery systems.
• Generic Drug Production: Essential for manufacturers producing generic versions of established tegafur-based chemotherapy medications.
• Biochemical Research: Used in laboratory studies to investigate mechanisms of action, resistance, and metabolism of fluoropyrimidine drugs.

Basic Information

Product Name	Tegafur
CAS No.	65732-47-0
Molecular Formula	C8H9FN2O3
Molecular Weight	200.17 g/mol
Synonyms	5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; Ftoraful; Fluorofur; 1-(2-Tetrahydrofuryl)-5-fluorouracil; NSC 148958; UFT (component); TS-1 (component); Ftorafur
EINECS	265-896-5

Quality Control

Our Tegafur is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications typically aligned with pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.