Description

Poly(2'-Bromo-2'-Deoxyadenylic Acid) is a synthetic, brominated oligonucleotide analog designed for advanced biochemical research and development. This modified nucleic acid polymer is critical for studying DNA structure, function, and interactions, particularly in the context of mutagenesis and molecular probes. It serves as an essential tool for researchers and developers in the fields of pharmaceutical discovery, molecular diagnostics, and academic biochemistry, where precise nucleotide modification is required.

Application

• Biochemical Research: Used as a substrate or probe in enzymatic studies, particularly with polymerases and nucleases, to investigate DNA synthesis and repair mechanisms.
• Antisense & Oligonucleotide Therapeutics: Serves as a key intermediate or model compound in the development of modified antisense oligonucleotides for therapeutic applications.
• Molecular Diagnostics: Employed in the design and development of specialized probes for detecting specific DNA sequences or mutations.
• Structural Biology: Utilized in X-ray crystallography and NMR studies to analyze the impact of halogenated bases on DNA duplex stability and conformation.
• Photochemical & Cross-linking Studies: Acts as a reagent in studies exploring photo-induced cross-linking of DNA to proteins or other biomolecules, leveraging the bromine atom's reactivity.

Basic Information

Product Name	Poly(2'-Bromo-2'-Deoxyadenylic Acid)
CAS No.	65456-05-5
Molecular Formula	(C10H11BrN5O6P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(2'-bromo-2'-deoxyadenosine 5'-monophosphate); Poly(Br-dAMP); 2'-Bromo-2'-deoxyadenylic acid homopolymer; Poly(2'-bromodeoxyadenylic acid); Brominated polydeoxyadenylic acid; Poly(2'-Br-dA); Oligonucleotide, 2'-bromo-2'-deoxyadenylic acid residues
EINECS	Contact for details

Quality Control

Our Poly(2'-Bromo-2'-Deoxyadenylic Acid) is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Quality is verified through a suite of analytical techniques including HPLC, UV-Vis spectroscopy, and gel electrophoresis. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight distribution, and identification is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to degradation. For long-term stability, store desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (UV)	Complies
Identification (HPLC)	Complies
Purity (HPLC)	≥ 95%
Solubility	Soluble in aqueous buffers, DMSO
Extinction Coefficient (ε)	~15,400 M-1cm-1 at 260 nm
Molecular Weight Range	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.