Description

(R)-β-Methyl-γ-Butyrolactone is a high-value chiral building block and intermediate of significant importance in asymmetric synthesis. Its enantiopure nature makes it a critical precursor for the production of pharmaceuticals, agrochemicals, and advanced materials where stereochemistry dictates biological activity and material properties. This compound is essential for research and manufacturing chemists in the pharmaceutical, fine chemical, and flavor & fragrance industries seeking to introduce the (R)-configured methyl-butyrolactone moiety into complex target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor and Fragrance Ingredient: Serves as a precursor for lactone-based flavor compounds, contributing to creamy, fruity, and coconut-like notes.
• Asymmetric Catalysis Research: Employed as a standard substrate or ligand precursor in the development and testing of new chiral catalysts.
• Polymer Chemistry: Acts as a monomer or co-monomer for synthesizing specialized biodegradable or functional polymers.
• Natural Product Synthesis: A valuable building block for the total synthesis of complex natural products containing chiral γ-lactone structures.

Basic Information

Product Name	(R)-β-Methyl-γ-Butyrolactone
CAS No.	65284-00-6
Molecular Formula	C5H8O2
Molecular Weight	100.12 g/mol
Synonyms	(R)-β-Methyl-γ-butyrolactone; (R)-3-Methyl-dihydrofuran-2(3H)-one; (R)-3-Methylbutyrolactone; (R)-3-Methyl-γ-butyrolactone; (R)-Pantolactone; (R)-Homopantolactone; (R)-3-Methyl-1,4-butanolide; (R)-3-Methyl-4-hydroxybutanoic acid lactone
EINECS	Contact for details

Quality Control

Our (R)-β-Methyl-γ-Butyrolactone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC or GC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess (ee), and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]	Contact for details
Refractive Index (n20D)	Contact for details
Density (g/mL, 20°C)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.