Description

8-(Chloroacetylaminoethylthio)Cyclic Amp is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signaling pathways. This compound is specifically engineered as a key synthetic intermediate or a biochemical tool for advanced research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of biochemistry, molecular pharmacology, and medicinal chemistry who require high-purity, specialized building blocks for probing cellular mechanisms or developing novel therapeutics.

Application

• Biochemical Research: Acts as a crucial intermediate in the synthesis of novel cAMP analogs for studying protein kinase A (PKA) and other cAMP-dependent signaling pathways.
• Pharmaceutical Development: Serves as a key building block in the research and synthesis of potential therapeutic agents targeting cardiovascular, neurological, and metabolic disorders.
• Probe Synthesis: Used to create affinity probes or labeled derivatives for investigating cAMP-binding proteins and their interactions within cells.
• Enzyme Studies: Employed as a substrate or inhibitor analog in enzymatic assays to study the activity and regulation of phosphodiesterases and adenylate cyclases.
• Cell Signaling Modulation: Utilized in experimental setups to modulate intracellular cAMP levels in a controlled manner, helping to elucidate complex signal transduction networks.

Basic Information

Product Name	8-(Chloroacetylaminoethylthio)Cyclic Amp
CAS No.	65259-76-9
Molecular Formula	C14H19ClN5O6PS
Molecular Weight	451.82 g/mol
Synonyms	8-[(2-Chloroacetamido)ethylthio]adenosine 3',5'-cyclic monophosphate; 8-(2-Chloroacetamidoethylthio)-cAMP; ChloroacetylcAMP derivative; cAMP-8-(2-chloroacetamidoethylthio); 8-AET-cAMP chloroacetamide; N-[2-[(6-Amino-9-β-D-ribofuranosyl-9H-purin-8-yl)thio]ethyl]-2-chloroacetamide 3',5'-cyclic phosphate
EINECS	Contact for details

Quality Control

Our 8-(Chloroacetylaminoethylthio)Cyclic Amp is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.