Description

Sirohydrochlorin is a vital tetrapyrrole intermediate in the biosynthesis of essential cofactors like vitamin B12 and heme. Its precise chemical structure makes it a critical compound for research and development in biochemistry and synthetic biology. This high-purity intermediate is primarily sought by the pharmaceutical, biotechnology, and advanced chemical synthesis industries for use in enzymatic studies, metabolic pathway analysis, and the production of complex biomolecules.

Application

• Biochemical Research: A key precursor for studying the biosynthesis pathways of cobalamin (Vitamin B12) and related tetrapyrroles.
• Enzymology Studies: Used as a substrate or standard in assays involving enzymes like sirohydrochlorin ferrochelatase and cobaltochelatase.
• Pharmaceutical Development: Serves as a building block in the research and synthesis of novel pharmaceuticals targeting metabolic disorders.
• Synthetic Biology: Employed in engineered metabolic pathways for the microbial production of high-value tetrapyrrole derivatives.
• Analytical Standard: Utilized as a high-purity reference standard in HPLC, LC-MS, and other analytical methods for quality control and research.
• Nutraceutical Research: Investigated for its role in the biotechnological production of vitamin B12 and other essential nutrients.

Basic Information

Product Name	Sirohydrochlorin
CAS No.	65207-12-7
Molecular Formula	C₄₂H₄₈N₄O₁₆
Molecular Weight	888.85 g/mol
Synonyms	Sirohydrochlorin; Sirohydrochlorin IX; 2,7,13,17-Tetrakis(2-carboxyethyl)-3,8,12,18-tetramethylcorphin-1,19-dicarboxylic acid; Factor II; DIBS; 1,19-Dicarboxy-2,7,13,17-tetrakis(2-carboxyethyl)-3,8,12,18-tetramethylcorphin; Uroporphyrinogen III trimethyl ester oxidation product
EINECS	Contact for details

Quality Control

Our Sirohydrochlorin is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Reddish-brown to purple solid
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Conforms to reference spectrum
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in alkaline aqueous solutions, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.