Description

n-(n-(4-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Phenylalanyl)-L-Glutamic Acid is a high-purity, complex biochemical compound of significant interest in advanced research and development. This molecule serves as a critical intermediate or reference standard in the synthesis and study of folate analogs and related therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in developing novel drug candidates, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel folate antagonists and chemotherapeutic agents.
• Biochemical Reference Standard: For use in analytical method development, validation, and quality control (QC) of related active pharmaceutical ingredients (APIs).
• Enzyme Inhibition Studies: Utilized in biochemical assays to study the mechanism and kinetics of dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Academic Research: For fundamental studies in medicinal chemistry, chemical biology, and the structure-activity relationships (SAR) of pteridine-based compounds.
• Process Development: Serves as a building block in the scale-up and optimization of synthetic routes for complex drug molecules.

Basic Information

Product Name	n-(n-(4-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Phenylalanyl)-L-Glutamic Acid
CAS No.	65118-40-3
Molecular Formula	C30H34N10O6
Molecular Weight	630.66 g/mol
Synonyms	N-[N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-phenylalanyl]-L-glutamic acid; Phenylalanine-glutamate folate analog; 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid phenylalanine glutamate conjugate; L-Glutamic acid, N-[N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-phenylalanyl]-; Folate-Phe-Glu conjugate
EINECS	Contact for details

Quality Control

Our production of this advanced biochemical adheres to stringent quality management systems. Each batch is characterized and tested using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all critical quality attributes. We support research and development with material suitable for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.