Description

Thrombocytin from Bothrops atrox venom is a highly purified serine protease enzyme derived from the venom of the Fer-de-Lance pit viper. This specific enzyme is a critical research tool for studying platelet aggregation, blood coagulation pathways, and hemostasis mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on cardiovascular and hematological disorders.

Application

• Biochemical Research: Used as a specific protease to activate platelets and study aggregation mechanisms in vitro.
• Coagulation Pathway Analysis: A key reagent for investigating the intrinsic and common pathways of blood clotting.
• Pharmaceutical Development: Employed in screening and evaluating potential antithrombotic and antiplatelet drug candidates.
• Diagnostic Reagent Production: Serves as a component in specialized diagnostic kits for assessing platelet function and coagulation disorders.
• Enzymology Studies: Used to characterize serine protease activity, kinetics, and inhibition profiles.
• Toxin & Venom Research: Essential for comparative studies on snake venom components and their physiological effects.

Basic Information

Product Name	Thrombocytin from Bothrops atrox venom
CAS No.	65099-56-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bothrops atrox thrombin-like enzyme; Batroxobin (Note: Batroxobin is a related but distinct enzyme, often used interchangeably in literature); Bothrops atrox serine protease; Platelet-activating enzyme; Venom coagulant enzyme; EC 3.4.21.74; Atroxase (less common); Thrombin-like enzyme from Bothrops atrox
EINECS	Contact for details

Quality Control

Our Thrombocytin is produced and tested under stringent quality management systems. Each batch is characterized for specific activity, purity, and absence of non-specific protease activity. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity (by SDS-PAGE and HPLC), specific activity, protein content, and endotoxin levels where applicable. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent loss of activity. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single major band
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Protein Content (Biuret)	Contact for details
Endotoxin (LAL)	< 1.0 EU/mg (if applicable)
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.