Description

4-(2-n-Maleimido)Methyl Benzoic Acid is a high-purity, heterobifunctional crosslinking agent featuring both a maleimide and a carboxylic acid functional group. This compound is critical for creating stable, site-specific conjugations between biomolecules, such as proteins and peptides, and various surfaces or other molecules. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced material science.

Application

• Bioconjugation Reagent: For the covalent attachment of peptides, proteins, or antibodies to carriers, surfaces, or other biomolecules via the maleimide-thiol click chemistry.
• Antibody-Drug Conjugate (ADC) Linker Precursor: Serves as a key intermediate in the synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• Surface Functionalization: Used to modify nanoparticles, biosensors, chromatographic media, and microarray slides with reactive maleimide groups for subsequent biomolecule immobilization.
• Polymer Modification: Enables the introduction of carboxylic acid handles into polymers or hydrogels for further chemical tailoring and biofunctionalization.
• Diagnostic Assay Development: Facilitates the stable labeling of detection antibodies or antigens in ELISA, lateral flow assays, and other immunoassays.
• Protein PEGylation: Acts as a linker for attaching polyethylene glycol (PEG) chains to specific sites on therapeutic proteins to enhance stability and pharmacokinetics.

Basic Information

Product Name	4-(2-n-Maleimido)Methyl Benzoic Acid
CAS No.	64987-81-1
Molecular Formula	C13H11NO5
Molecular Weight	261.23 g/mol
Synonyms	4-(2-Maleimidomethyl)benzoic acid; 4-(Maleimidomethyl)benzoic Acid; 4-Maleimidomethylbenzoic Acid; 4-(N-Maleimidomethyl)benzoic Acid; 4-(Maleimidomethyl)benzoic acid; 4-Maleimidobenzoic Acid derivative; MMB Acid; 4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-ylmethyl)benzoic Acid; 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 4-(aminomethyl)benzoate (related structure).
EINECS	Contact for details

Quality Control

Our 4-(2-n-Maleimido)Methyl Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; slightly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.