Description

11-Oxo-Betamethasone Dipropionate is a synthetic corticosteroid derivative, serving as a key pharmaceutical intermediate in the synthesis of advanced anti-inflammatory and immunosuppressive agents. Its value lies in providing a versatile chemical backbone for developing potent topical and systemic corticosteroid formulations. This compound is essential for research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on dermatological, ophthalmic, and respiratory therapeutics.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of high-potency corticosteroid APIs like Betamethasone Dipropionate and its analogs.
• Research & Development: Critical reference standard and starting material in medicinal chemistry for developing new glucocorticoid receptor agonists.
• Topical Formulation Development: Used in R&D for creams, ointments, and lotions targeting inflammatory skin conditions such as psoriasis, eczema, and dermatitis.
• Process Chemistry: Serves as a key intermediate in scale-up and optimization of manufacturing processes for steroid-based drugs.
• Analytical Standard: Employed as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and NMR method development and validation.

Basic Information

Product Name	11-Oxo-Betamethasone Dipropionate
CAS No.	64967-90-4
Molecular Formula	C₂₈H₃₇FO₇
Molecular Weight	504.59 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione 17,21-dipropionate; Betamethasone 17,21-Dipropionate 11-Oxime; 11-Oxobetamethasone 17,21-Dipropionate; 11-Ketobetamethasone Dipropionate; NSC 39471; 11-Dehydrobetamethasone Dipropionate
EINECS	Contact for details

Quality Control

Our 11-Oxo-Betamethasone Dipropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for pharmaceutical intermediate use. Certificates of Analysis (COA) with batch-specific data are provided and can be tailored to meet client-specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.