Description

Glutathione-S-Acetaminophen Conjugate CAS NO 64889-81-2 is a specific metabolite formed from the conjugation of glutathione with acetaminophen (paracetamol). This compound is of critical importance in toxicological and pharmacological research as a key biomarker for studying drug-induced liver injury and metabolic pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on hepatotoxicity studies, biomarker assay development, and advanced metabolic profiling.

Application

• Biomarker Research: Used as a reference standard in studies investigating acetaminophen-induced hepatotoxicity and the role of the glutathione pathway.
• Diagnostic Assay Development: Serves as a critical calibrant or control in the development of LC-MS/MS or ELISA-based assays for detecting drug metabolites in biological samples.
• Metabolic Pathway Analysis: Essential for in vitro and in vivo studies to map and quantify the formation of reactive metabolite conjugates.
• Toxicology & Safety Assessment: Employed in pharmaceutical development to understand and mitigate the toxicological profiles of new chemical entities.
• Reference Standard for Quality Control: Used by manufacturers of clinical diagnostics and testing laboratories to ensure the accuracy of metabolite detection.
• Academic Research: A key reagent for universities and research institutes studying cytochrome P450 metabolism, oxidative stress, and cellular defense mechanisms.

Basic Information

Product Name	Glutathione-S-Acetaminophen Conjugate
CAS No.	64889-81-2
Molecular Formula	C20H27N6O9S
Molecular Weight	527.53 g/mol
Synonyms	3-(Glutathion-S-yl)acetaminophen; APAP-GSH Conjugate; N-Acetyl-p-benzoquinone imine-Glutathione Adduct; Paracetamol Glutathione Conjugate; Acetaminophen Glutathione Adduct; GSH-APAP; S-(5-Acetamido-2-hydroxyphenyl)glutathione; Glutathionyl-acetaminophen
EINECS	Contact for details

Quality Control

Our Glutathione-S-Acetaminophen Conjugate is produced and handled under strict quality protocols suitable for research and diagnostic applications. Each batch is characterized using advanced analytical techniques including HPLC and mass spectrometry to ensure identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment to guarantee traceability and consistency for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.