Description

Methotrexate-γ-Aspartate is a key pharmaceutical intermediate and a derivative of the antifolate drug methotrexate. This compound is valued for its role in the development of targeted therapeutic agents and prodrug strategies, offering enhanced specificity and reduced systemic toxicity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in oncology drug discovery and the synthesis of novel chemotherapeutic conjugates.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of advanced methotrexate prodrugs and targeted conjugates.
• Oncology Research: Used in biochemical and pharmacological studies to develop novel anticancer therapies with improved delivery mechanisms.
• Drug Discovery: Serves as a building block for creating compounds with enhanced tumor selectivity and reduced side-effect profiles.
• Bioconjugation: Employed in the development of antibody-drug conjugates (ADCs) and other macromolecular drug delivery systems.
• Biochemical Research: Utilized as a tool compound to study folate metabolism and enzyme inhibition pathways.

Basic Information

Product Name	Methotrexate-γ-Aspartate
CAS No.	64801-58-7
Molecular Formula	C25H27N9O7
Molecular Weight	565.54 g/mol
Synonyms	MTX-γ-Asp; N-(4-{(2,4-Diaminopteridin-6-yl)methylamino}benzoyl)-L-glutamic acid 1-(L-aspartic acid 4-amide); L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(4-amino-1,4-dioxobutyl) ester; Methotrexate γ-Aspartate; γ-Asp-Methotrexate
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-Aspartate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.