Description

Glutathione-Dehydroretronecine Conjugate is a specialized biochemical conjugate formed between the endogenous antioxidant glutathione and the pyrrolizidine alkaloid metabolite dehydroretronecine. This compound is of significant interest in toxicological and pharmacological research for studying the detoxification pathways and bioactivation mechanisms of pyrrolizidine alkaloids. It serves as a critical reference standard and research tool for scientists in pharmaceutical development, forensic toxicology, and natural product safety assessment who require high-purity, well-characterized metabolites.

Application

• Metabolite Reference Standard: Used as a certified reference material (CRM) for the accurate quantification of pyrrolizidine alkaloid metabolites in biological and botanical samples via LC-MS/MS or HPLC.
• Toxicology Research: Essential for investigating the formation of glutathione adducts as a key detoxification pathway, helping to elucidate the hepatotoxic mechanisms of pyrrolizidine alkaloids.
• Biomarker Development: Employed in the development and validation of analytical methods for detecting specific exposure biomarkers in food safety and phytotoxin monitoring.
• Drug Metabolism Studies: Utilized in in vitro and in vivo studies to understand the metabolic fate and potential reactive intermediates of alkaloid-containing compounds.
• Quality Control for Herbal Products: Serves as a critical standard for laboratories ensuring the safety of herbal supplements and teas by testing for toxic pyrrolizidine alkaloid derivatives.

Basic Information

Product Name	Glutathione-Dehydroretronecine Conjugate
CAS No.	64660-86-2
Molecular Formula	C20H31N5O9S
Molecular Weight	517.55 g/mol
Synonyms	Dehydroretronecine-Glutathione Conjugate; GSH-Dehydroretronecine Adduct; 7-Glutathionyl-1-hydroxymethyl-6,7-dihydro-5H-pyrrolizine; Glutathione Adduct of Dehydroretronecine; Pyrrolizidine Alkaloid Metabolite; DHR-GSH Conjugate; (R)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(7-hydroxymethyl-6,7-dihydro-5H-pyrrolizin-1-yl)sulfanyl]ethyl]carbamoyl}butanoic acid
EINECS	Contact for details

Quality Control

Our Glutathione-Dehydroretronecine Conjugate is manufactured and handled under strict quality protocols suitable for research and analytical applications. Each batch undergoes rigorous identity confirmation and purity analysis using advanced techniques such as NMR, HPLC, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and analytical data to ensure traceability and support your regulatory and publication requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature before opening to minimize moisture condensation. This material is hygroscopic and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.