Description

Amitriptyline Metabolite (+/-)- is a key chiral metabolite of the tricyclic antidepressant amitriptyline. This compound is of significant value in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and pharmacogenetics. It serves as a critical reference standard and intermediate for analytical laboratories, toxicology studies, and manufacturers of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of amitriptyline and its metabolites in drug testing and bioanalytical studies.
• Metabolite Research: Essential for investigating the metabolic pathways, bioavailability, and elimination profiles of amitriptyline in preclinical and clinical research.
• Forensic Toxicology: Employed as a calibrator or control in forensic laboratories for the accurate detection and quantification of amitriptyline in biological samples.
• Active Pharmaceutical Ingredient (API) Development: Acts as a crucial intermediate or starting material in the synthesis of novel pharmaceutical compounds or diagnostic agents.
• Quality Control (QC) & Assurance: Utilized by API manufacturers and QC laboratories to validate analytical methods, such as HPLC or LC-MS, ensuring product purity and consistency.
• Pharmacogenomic Studies: Supports research into how genetic variations affect individual responses to amitriptyline therapy.

Basic Information

Product Name	Amitriptyline Metabolite (+/-)-
CAS No.	64520-05-4
Molecular Formula	C20H23N
Molecular Weight	277.40 g/mol
Synonyms	10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine; E-10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine; trans-10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine; (E)-Amitriptyline Metabolite; trans-Amitriptyline Metabolite; Amitriptyline Impurity; Nortriptyline Related Compound
EINECS	Contact for details

Quality Control

Our Amitriptyline Metabolite (+/-)- is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, identity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.