Description

4-Deoxy-20-Hydroxy-4-[2-(1-Hydroxyethyl)-1-Pyrrolidinyl]Rifamycin CAS NO 64419-06-3 is a semi-synthetic derivative of the rifamycin class of antibiotics, characterized by its modified ansamycin structure. This compound is of significant interest for its potential role in the research and development of novel antimicrobial agents, particularly against resistant bacterial strains. It serves as a critical pharmaceutical intermediate and reference standard for researchers and manufacturers in the life sciences sector.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced rifamycin-based antibiotics and investigational drugs.
• Antimicrobial Research: Used as a reference compound in microbiological studies to explore structure-activity relationships and mechanisms of action against Mycobacterium and other bacteria.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Employed in studies targeting bacterial RNA polymerase inhibition for novel therapeutic pathways.
• Process Development: Utilized in scaling up and optimizing synthetic routes for next-generation antibiotic production.

Basic Information

Product Name	4-Deoxy-20-Hydroxy-4-[2-(1-Hydroxyethyl)-1-Pyrrolidinyl]Rifamycin
CAS No.	64419-06-3
Molecular Formula	C43H58N2O12
Molecular Weight	794.93 g/mol
Synonyms	4-Deoxy-20-hydroxy-4-[2-(1-hydroxyethyl)-1-pyrrolidinyl]rifamycin S; 4-Deoxy-4-[2-(1-hydroxyethyl)-1-pyrrolidinyl]-20-hydroxyrifamycin S; Rifamycin Derivative 64419-06-3; 4-Deoxy-20-hydroxy-4-(2-(1-hydroxyethyl)-1-pyrrolidinyl)rifamycin; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1-oxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-5-yl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Deoxy-20-Hydroxy-4-[2-(1-Hydroxyethyl)-1-Pyrrolidinyl]Rifamycin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.