Description

3,3'-Diiodothyronine-4-Sulfate is a sulfated derivative of the thyroid hormone metabolite, diiodothyronine. This compound is of significant interest in biochemical and pharmaceutical research for studying thyroid hormone metabolism, transport, and inactivation pathways. It serves as a critical reference standard and intermediate for researchers and developers in the fields of endocrinology and metabolic disease. Target users include pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the quantification and qualification of thyroid hormone metabolites in biological samples via LC-MS or HPLC.
• Biochemical Research: Essential for in-vitro studies investigating the sulfation pathway of thyroid hormones, its role in hormone regulation, and metabolic inactivation.
• Diagnostic Development: Serves as a key antigen or calibrator in the development of immunoassays (e.g., ELISA) for detecting sulfated thyroid hormone derivatives in clinical diagnostics.
• Metabolite Synthesis: Acts as a specialized intermediate or precursor in the custom synthesis of other labeled or modified thyroid hormone analogs for tracer studies.
• Toxicology & DMPK Studies: Employed in drug metabolism and pharmacokinetics (DMPK) research to understand the disposition and clearance pathways of iodinated compounds.

Basic Information

Product Name	3,3'-Diiodothyronine-4-Sulfate
CAS No.	64192-57-0
Molecular Formula	C15H13I2NO7S
Molecular Weight	621.14 g/mol
Synonyms	3,3'-T2S; 3,3'-Diiodothyronine Sulfate; 3,3'-Diiodo-L-thyronine 4-Sulfate; T2 Sulfate; 4-Sulfooxy-3,5-diiodophenyl-4-hydroxy-3-iodophenylalanine; (2S)-2-Amino-3-[4-(4-sulfooxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our 3,3'-Diiodothyronine-4-Sulfate is produced under a quality-managed system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, MS, and NMR characterization. The product is suitable for use as a research-grade reference material. Specifications can be developed to meet the requirements of specific research or diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤2.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.