Description

Adenosine 5'-Diphosphate 2',3'-Dialdehyde is a chemically modified nucleotide analog where the ribose sugar moiety has been oxidized to a dialdehyde. This compound is a critical biochemical tool, primarily valued for its ability to act as an irreversible inhibitor or affinity label for enzymes and receptors that bind ATP or ADP, due to its reactive aldehyde groups. It is essential for researchers in biochemistry, enzymology, and molecular pharmacology studying nucleotide-binding sites, energy metabolism, and signal transduction pathways. The product is supplied under the CAS registry number 64060-84-0.

Application

• Enzyme Inhibition Studies: Used as an active-site directed, irreversible inhibitor for ATP/ADP-dependent enzymes like kinases, ATPases, and synthetases.
• Affinity Labeling & Protein Cross-linking: The reactive dialdehyde groups enable covalent modification and cross-linking of nucleotide-binding proteins for structural and functional analysis.
• Biochemical Research Reagent: A key substrate analog in mechanistic studies of phosphorylation, energy transfer, and allosteric regulation.
• Probe Development: Serves as a precursor for synthesizing fluorescent or biotinylated probes to visualize or isolate nucleotide-binding proteins.
• Metabolic Pathway Analysis: Useful in studying purinergic signaling and adenosine-related metabolic pathways in cellular systems.
• Pharmaceutical R&D: Employed in drug discovery programs targeting purinergic receptors and metabolic enzymes for therapeutic intervention.

Basic Information

Product Name	Adenosine 5'-Diphosphate 2',3'-Dialdehyde
CAS No.	64060-84-0
Molecular Formula	C10H13N5O10P2
Molecular Weight	425.19 g/mol
Synonyms	2',3'-Dialdehyde ADP; Periodate-oxidized ADP; o-ADP; ADP Dialdehyde; Adenosine-5'-diphospho-2',3'-dialdehyde; Oxidized Adenosine Diphosphate; 5'-ADP-2',3'-dial; ADP-2',3'-dialdehyde
EINECS	Contact for details

Quality Control

Our Adenosine 5'-Diphosphate 2',3'-Dialdehyde is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and mass spectrometry for structural confirmation, and tests for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and bulk quantities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.