Description

2-Azidoadenosine 3',5'-Diphosphate is a chemically modified nucleotide analog featuring an azido group at the 2-position of the adenine base. This compound is a critical biochemical tool for studying and manipulating nucleotide-binding proteins and enzymes, particularly in the field of signal transduction. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical assay development, and proteomics for applications such as affinity labeling, cross-linking studies, and the development of novel enzyme inhibitors.

Application

• Biochemical Research & Proteomics: Used as an affinity probe and photo-crosslinking agent for identifying and characterizing adenosine nucleotide-binding sites in proteins and enzymes.
• Enzyme Inhibition Studies: Serves as a potent, mechanism-based inhibitor for kinases, ATPases, and other enzymes utilizing ATP or ADP as substrates.
• Signal Transduction Pathway Analysis: A key tool for investigating cellular signaling pathways involving cyclic nucleotides and energy metabolism.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) assays and in the design of novel therapeutic agents targeting nucleotide-dependent processes.
• Bioconjugation & Labeling: The reactive azido group enables click chemistry applications for site-specific labeling of biomolecules.
• Academic & Institutional Research: Fundamental research tool in universities and research institutes for studying enzyme kinetics and protein-ligand interactions.

Basic Information

Product Name	2-Azidoadenosine 3',5'-Diphosphate
CAS No.	64020-53-7
Molecular Formula	C15H18N9O11P2
Molecular Weight	586.31 g/mol
Synonyms	2-Azido-ADP; 2-N3-ADP; Adenosine 3',5'-diphosphate, 2-azido-; 2-Azidoadenosine-3',5'-bisphosphate; 2-Azido-adenosine-3',5'-diphosphate; 2-Azido-3',5'-ADP; 2-N3ADP
EINECS	Contact for details

Quality Control

Our 2-Azidoadenosine 3',5'-Diphosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term stability, keep the material desiccated. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.