Description

Dipivefrin Hydrochloride is a prodrug of epinephrine, specifically engineered for enhanced corneal penetration and stability. This compound is a critical active pharmaceutical ingredient (API) in the formulation of ophthalmic solutions for managing intraocular pressure. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for glaucoma and ocular hypertension. Our supply ensures high purity and consistent quality for reliable production and research outcomes.

Application

• Ophthalmic Pharmaceutical Manufacturing: Primary use as the key API in prescription eye drops for glaucoma therapy.
• Research & Development: Serves as a reference standard and starting material in ophthalmic drug discovery and pharmacokinetic studies.
• Generic Drug Formulation: Essential for producing generic versions of branded dipivefrin hydrochloride ophthalmic solutions.
• Veterinary Ophthalmology: Used in developing ophthalmic treatments for animals with similar ocular pressure conditions.
• Controlled-Release Drug Delivery Systems: Investigated for use in advanced ocular implants and sustained-release formulations.

Basic Information

Item	Detail
Product Name	Dipivefrin Hydrochloride
CAS No.	64019-93-8
Molecular Formula	C19H29NO5 • HCl
Molecular Weight	403.90 g/mol
Synonyms	Dipivefrin HCl; Dipivalyl Epinephrine Hydrochloride; Dipivalyl Adrenaline Hydrochloride; DPE; Glaucothil; Propine (brand name referent); (RS)-2-(3,4-Dihydroxyphenyl)-2-[(2,2-dimethyl-1-oxopropoxy)methylamino]ethyl pivalate hydrochloride; 4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol 3,4-bis(2,2-dimethylpropanoate) hydrochloride
EINECS	Contact for details

Quality Control

Our Dipivefrin Hydrochloride is manufactured and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical applications, with testing typically including identification, assay, impurity profiling, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.