Description

1',3'-Bis[1,2-Dimyristoyl-Sn-Glycero-3-Phospho]-Sn-Glycerol (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a cardiolipin analog, essential for creating biomimetic membrane systems. Its value lies in providing a critical, well-defined structural component for advanced life science research and pharmaceutical development. This compound is primarily needed by researchers and formulators in liposome and nanoparticle drug delivery, membrane biophysics studies, and diagnostic assay development.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural phospholipid for creating stable, targeted drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Biomimetic Membrane Models: Used in the construction of artificial membranes and vesicles (e.g., giant unilamellar vesicles - GUVs) for studying membrane protein function, fusion, and permeability.
• Diagnostic Reagents: Serves as a critical antigenic component in immunoassays, such as those for detecting anti-cardiolipin antibodies (aCL) in autoimmune disease diagnostics.
• Cell Biology Research: Employed in studies of mitochondrial membrane dynamics, apoptosis, and cellular signaling pathways where cardiolipin plays a vital role.
• Pharmaceutical Excipient: Investigated as a functional excipient to enhance the stability and efficacy of complex parenteral formulations.
• Surface Chemistry & Biosensors: Used to create supported lipid bilayers (SLBs) on sensor chips for real-time interaction analysis (e.g., SPR, QCM-D).

Basic Information

Product Name	1',3'-Bis[1,2-Dimyristoyl-Sn-Glycero-3-Phospho]-Sn-Glycerol (Ammonium Salt)
CAS No.	63988-20-5
Molecular Formula	C73H144N2O17P2
Molecular Weight	1384.88 g/mol
Synonyms	1',3'-Bis(1,2-ditetradecanoyl-sn-glycero-3-phospho)-sn-glycerol ammonium salt; Cardiolipin (C14:0) ammonium salt; Tetramyristoyl Cardiolipin ammonium salt; DMPC-Cardiolipin; CL(14:0/14:0/14:0/14:0) ammonium salt; 1,3-Bis(1,2-dimyristoyl-sn-glycero-3-phospho)-sn-glycerol ammonium salt; L-α-Phosphatidyl-D-myo-inositol-3,4-bisphosphate ammonium salt (related structural analog).
EINECS	Contact for details

Quality Control

Our synthetic phospholipids are produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS analyses. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This hygroscopic (moisture-sensitive) material should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term stability, store as supplied.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98.0%
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffer
Residual Solvents (GC)	Meets ICH limits
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.